Adaptive Differentiation ofPlasmodium falciparumPopulations Inferred from Single‐Nucleotide Polymorphisms (SNPs) Conferring Drug Resistance and from Neutral SNPs

Mutation Rate Distribution Inferred from Coincident SNPs and Coincident Substitutions

Mutation rate variation has the potential to bias evolutionary inference, particularly when rates become much higher than the mean. We first confirm prior work that inferred the existence of cryptic, site-specific rate variation on the basis of coincident polymorphisms-sites that are segregating in both humans and chimpanzees. Then we extend this observation to a longer evolutionary timescale b...

SingleNucleotide Polymorphisms ( SNPs ) Detected in thegeipC Gene Region of Stroptococcus mutans

StrePtocoeetes m"tan glucan'binding protein C encoded by the gttPC gene is an important virulent factor in human denta1 caries, Howeveg a nonsense mutation and several nucleotide substitutions in the gtipC gene have been detected in strain GS-5, Therefore, gaPC nucleotide sequences from 17 additional S, thutans strains were determined and single nucleotide polymorph{sms were detected. Both cons...

From SNPs to Can genes

Mining SNPs from EST databases.

There is considerable interest in the discovery and characterization of single nucleotide polymorphisms (SNPs) to enable the analysis of the potential relationships between human genotype and phenotype. Here we present a strategy that permits the rapid discovery of SNPs from publicly available expressed sequence tag (EST) databases. From a set of ESTs derived from 19 different cDNA libraries, w...

Improved heritability estimation from genome-wide SNPs.

Estimation of narrow-sense heritability, h(2), from genome-wide SNPs genotyped in unrelated individuals has recently attracted interest and offers several advantages over traditional pedigree-based methods. With the use of this approach, it has been estimated that over half the heritability of human height can be attributed to the ~300,000 SNPs on a genome-wide genotyping array. In comparison, ...